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Index > Protein center > FUT2(Gene name) > Human
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  • FUT2 (Gene name),
  • Galactoside 2-alpha-L-fucosyltransferase 2 (Protein name ),  FUT2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FUT2(SEC2);
    Protein name:
    Galactoside 2-alpha-L-fucosyltransferase 2;
    Alternative:
    Fucosyltransferase 2;Alpha(1,2)FT 2;SE2;GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2;Secretor factor(Se);Secretor blood group alpha-2-fucosyltransferase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.
    Subcellular Location:
    Golgi apparatus Golgi stack membrane Single-pass type II membrane protein Membrane-bound form in trans cisternae of Golgi.
    Protein Attributes:
    Sequence length:
    343
    Sequence:
    50:
    MLVVQMPFSF | PMAHFILFVF | TVSTIFHVQQ | RLAKIQAMWE | LPVQIPVLAS | 
    100:
    TSKALGPSQL | RGMWTINAIG | RLGNQMGEYA | TLYALAKMNG | RPAFIPAQMH | 
    150:
    STLAPIFRIT | LPVLHSATAS | RIPWQNYHLN | DWMEEEYRHI | PGEYVRFTGY | 
    200:
    PCSWTFYHHL | RQEILQEFTL | HDHVREEAQK | FLRGLQVNGS | RPGTFVGVHV | 
    250:
    RRGDYVHVMP | KVWKGVVADR | RYLQQALDWF | RARYSSLIFV | VTSNGMAWCR | 
    300:
    ENIDTSHGDV | VFAGDGIEGS | PAKDFALLTQ | CNHTIMTIGT | FGIWAAYLTG | 
    343:
    GDTIYLANYT | LPDSPFLKIF | KPEAAFLPEW | TGIAADLSPL | LKH
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    E11626h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    E11626b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    MSDS:
    Please sign in first.
    ELISA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    E11626m
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    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    E11626r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    E11626p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    U11626m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    U11626h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    U11626b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    U11626p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    U11626r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    P11626Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Polyclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Polyclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Polyclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    P11626Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Cat.:
    P11626Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Monoclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Monoclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Monoclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Monoclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Monoclonal Antibody for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Protein for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Protein for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Protein for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Protein for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Protein for Human Galactoside 2-alpha-L-fucosyltransferase 2
    Protein for Human Galactoside 2-alpha-L-fucosyltransferase 2

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    References
    1. 1.
      "Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype."
      Kelly R.J. , Rouquier S. , Giorgi D. , Lennon G.G. , Lowe J.B.
      J. Biol. Chem.270:4640-4649(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG)
    2. 2.
      "Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals."
      Kudo T. , Iwasaki H. , Nishihara S. , Shinya N. , Ando T. , Narimatsu I. , Narimatsu H.
      J. Biol. Chem.271:9830-9837(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM SHORT);VARIANT PHE-140
    3. 3.
      "Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)."
      Koda Y. , Soejima M. , Wang B. , Kimura H.
      Eur. J. Biochem.246:750-755(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);VARIANT PHE-140
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2005-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-25; CYS-138; ASN-172 AND SER-258
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG);VARIANT PHE-140
    6. 6.
      "Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency."
      Koda Y. , Soejima M. , Liu Y. , Kimura H.
      Am. J. Hum. Genet.59:343-350(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-343
    7. 7.
      "Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa."
      Liu Y. , Koda Y. , Soejima M. , Pang H. , Schlaphoff T. , du Toit E.D. , Kimura H.
      Hum. Genet.103:204-210(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-25; CYS-138 AND ASN-172
    8. 8.
      "Common variants of FUT2 are associated with plasma vitamin B12 levels."
      Hazra A. , Kraft P. , Selhub J. , Giovannucci E.L. , Thomas G. , Hoover R.N. , Chanock S.J. , Hunter D.J.
      Nat. Genet.40:1160-1162(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN B12QTL1
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